Incubation Period Duration and Severity of Clinical Disease Following Severe Acute Respiratory Syndrome Coronavirus Infection
Identifieur interne : 000124 ( France/Analysis ); précédent : 000123; suivant : 000125Incubation Period Duration and Severity of Clinical Disease Following Severe Acute Respiratory Syndrome Coronavirus Infection
Auteurs : Victor Virlogeux [France, République populaire de Chine] ; Vicky J. Fang [République populaire de Chine] ; Joseph T. Wu [République populaire de Chine] ; Lai-Ming Ho [République populaire de Chine] ; J. S. Malik Peiris [République populaire de Chine] ; Gabriel M. Leung [République populaire de Chine] ; Benjamin J. Cowling [République populaire de Chine]Source :
- Epidemiology (Cambridge, Mass.) [ 1044-3983 ] ; 2015.
Abstract
Few previous studies have investigated the association between the severity of an infectious disease and the length of incubation period.
We estimated the association between the length of the incubation period and the severity of infection with the severe acute respiratory syndrome (SARS) coronavirus, using data from the epidemic in 2003 in Hong Kong.
We estimated the incubation period of SARS based on a subset of patients with available data on exposure periods and a separate subset of patients in a putative common source outbreak, and we found significant associations between shorter incubation period and greater severity in both groups after adjusting for potential confounders.
Our findings suggest that patients with a shorter incubation period proceeded to have more severe disease. Further studies are needed to investigate potential biological mechanisms for this association.
Url:
DOI: 10.1097/EDE.0000000000000339
PubMed: 26133021
PubMed Central: 4889459
Affiliations:
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PMC:4889459Le document en format XML
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Cowling</name><affiliation wicri:level="1"><nlm:aff id="A2">WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26133021</idno><idno type="pmc">4889459</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889459</idno><idno type="RBID">PMC:4889459</idno><idno type="doi">10.1097/EDE.0000000000000339</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000D41</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D41</idno><idno type="wicri:Area/Pmc/Curation">000D41</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D41</idno><idno type="wicri:Area/Pmc/Checkpoint">000796</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000796</idno><idno type="wicri:Area/Ncbi/Merge">002A91</idno><idno type="wicri:Area/Ncbi/Curation">002A91</idno><idno type="wicri:Area/Ncbi/Checkpoint">002A91</idno><idno type="wicri:doubleKey">1044-3983:2015:Virlogeux V:incubation:period:duration</idno><idno type="wicri:Area/Main/Merge">001304</idno><idno type="wicri:Area/Main/Curation">001302</idno><idno type="wicri:Area/Main/Exploration">001302</idno><idno type="wicri:Area/France/Extraction">000124</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Incubation Period Duration and Severity of Clinical Disease Following Severe Acute Respiratory Syndrome Coronavirus Infection</title><author><name sortKey="Virlogeux, Victor" sort="Virlogeux, Victor" uniqKey="Virlogeux V" first="Victor" last="Virlogeux">Victor Virlogeux</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Biology, Ecole Normale Supérieure de Lyon, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Biology, Ecole Normale Supérieure de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Fang, Vicky J" sort="Fang, Vicky J" uniqKey="Fang V" first="Vicky J." last="Fang">Vicky J. Fang</name><affiliation wicri:level="1"><nlm:aff id="A2">WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Joseph T" sort="Wu, Joseph T" uniqKey="Wu J" first="Joseph T." last="Wu">Joseph T. Wu</name><affiliation wicri:level="1"><nlm:aff id="A2">WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Ho, Lai Ming" sort="Ho, Lai Ming" uniqKey="Ho L" first="Lai-Ming" last="Ho">Lai-Ming Ho</name><affiliation wicri:level="1"><nlm:aff id="A2">WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Malik Peiris, J S" sort="Malik Peiris, J S" uniqKey="Malik Peiris J" first="J. S." last="Malik Peiris">J. S. Malik Peiris</name><affiliation wicri:level="1"><nlm:aff id="A2">WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Centre of Influenza Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Influenza Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Leung, Gabriel M" sort="Leung, Gabriel M" uniqKey="Leung G" first="Gabriel M." last="Leung">Gabriel M. Leung</name><affiliation wicri:level="1"><nlm:aff id="A2">WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Cowling, Benjamin J" sort="Cowling, Benjamin J" uniqKey="Cowling B" first="Benjamin J." last="Cowling">Benjamin J. Cowling</name><affiliation wicri:level="1"><nlm:aff id="A2">WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author></analytic><series><title level="j">Epidemiology (Cambridge, Mass.)</title><idno type="ISSN">1044-3983</idno><idno type="eISSN">1531-5487</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Few previous studies have investigated the association between the severity of an infectious disease and the length of incubation period.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We estimated the association between the length of the incubation period and the severity of infection with the severe acute respiratory syndrome (SARS) coronavirus, using data from the epidemic in 2003 in Hong Kong.</p></sec><sec id="S3"><title>Results</title><p id="P3">We estimated the incubation period of SARS based on a subset of patients with available data on exposure periods and a separate subset of patients in a putative common source outbreak, and we found significant associations between shorter incubation period and greater severity in both groups after adjusting for potential confounders.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Our findings suggest that patients with a shorter incubation period proceeded to have more severe disease. Further studies are needed to investigate potential biological mechanisms for this association.</p></sec></div></front></TEI><affiliations><list><country><li>France</li><li>République populaire de Chine</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Virlogeux, Victor" sort="Virlogeux, Victor" uniqKey="Virlogeux V" first="Victor" last="Virlogeux">Victor Virlogeux</name></region></country><country name="République populaire de Chine"><noRegion><name sortKey="Virlogeux, Victor" sort="Virlogeux, Victor" uniqKey="Virlogeux V" first="Victor" last="Virlogeux">Victor Virlogeux</name></noRegion><name sortKey="Cowling, Benjamin J" sort="Cowling, Benjamin J" uniqKey="Cowling B" first="Benjamin J." last="Cowling">Benjamin J. Cowling</name><name sortKey="Fang, Vicky J" sort="Fang, Vicky J" uniqKey="Fang V" first="Vicky J." last="Fang">Vicky J. Fang</name><name sortKey="Ho, Lai Ming" sort="Ho, Lai Ming" uniqKey="Ho L" first="Lai-Ming" last="Ho">Lai-Ming Ho</name><name sortKey="Leung, Gabriel M" sort="Leung, Gabriel M" uniqKey="Leung G" first="Gabriel M." last="Leung">Gabriel M. Leung</name><name sortKey="Malik Peiris, J S" sort="Malik Peiris, J S" uniqKey="Malik Peiris J" first="J. S." last="Malik Peiris">J. S. Malik Peiris</name><name sortKey="Malik Peiris, J S" sort="Malik Peiris, J S" uniqKey="Malik Peiris J" first="J. S." last="Malik Peiris">J. S. Malik Peiris</name><name sortKey="Wu, Joseph T" sort="Wu, Joseph T" uniqKey="Wu J" first="Joseph T." last="Wu">Joseph T. Wu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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